1Nadya Azura, 2Desy Armalina, 3Indah Saraswati, 4Hermawan Istiadi, 5Lusiana Batubara
1Undergraduate Program, Faculty of Medicine, Diponegoro University
2Department of Histology, Faculty of Medicine, Diponegoro University
3,5Department of Medical Biology and Biochemistry, Faculty of Medicine, Diponegoro University
4Department of Anatomical Pathology, Faculty of Medicine, Diponegoro University
DOI : https://doi.org/10.47191/ijmra/v7-i07-20Google Scholar Download Pdf
ABSTRACT:
Cigarette smoke contains toxic components, carbon monoxide, hydrogen cyanide, carbon dioxide, and tar, which can trigger the formation of ROS (Reactive Oxygen Species) and reduce antioxidant reserves, which impact oxidative stress and are known to cause damage to liver cell membranes. Red dragon fruit (Hylocereus polyrhizus) is a fruit that is rich in antioxidants that inhibit ROS and prevent damage to liver cells by cigarette smoke. This study aims to assess the effect of administering red dragon fruit juice on liver microscopic images in Wistar rats exposed to cigarette smoke. It was an experimental study with a post-test-only control group design. Thirty-five male Wistar rats (Rattus novergicus) were randomized into five groups. Four groups were exposed to cigarette smoke (K-, P1, P2, and P3), and the fifth group was used as a control (K). All the P-groups were given red dragon fruit juice 2 g/2.5 ml, 4 g/2.5 ml, and 8 g/2.5 ml, respectively, for twenty-eight days. On the 29th day, the livers of Wistar rats were taken for preparation and microscopic observation. The research data were analyzed using the Kruskall-Wallis and Mann-Whitney post hoc tests to determine group differences. The average liver cell damage in K, K-, P1, P2, and P3 were 1.23, 2.51, 1.57, 1.51, and 1.43, respectively. There was a significant difference in damage between the K- group and the P1 (p = 0.002), P2 (p = 0.004), and P3 (p = 0.002) groups. The administration of red dragon fruit juice can protect the liver cells of rats exposed to cigarette smoke.
KEYWORDS:Red Dragon Fruit Juice; Liver; Microscopic; Cigarette smoke
REFERENCES1) Fajar Kurniawan. Urgensi Meratifikasi Framework Convention on Tobacco Control (Fctc) Dalam Upaya Pengendalian Konsumsi Tembakau Di Indonesia. J Huk Pembang [Internet]. 2021;1:29. Available from: https://scholarhub.ui.ac.id/dharmasisyaAvailableat:https://scholarhub.ui.ac.id/dharmasisya/vol1/iss1/29
2) Riset Dinas Kesehatan. Laporan Riskesdas 2018 Nasional.pdf. Lembaga Penerbit Balitbangkes. 2018.
3) Roza YN, Oenzil F, Pertiwi D. Hubungan antara Merokok dan Tingkat Aktivitas Aminotransferase Serum pada Pegawai Kantor. J Kesehat Andalas. 2017;6(2):409.
4) Ulilalbab A, Wirjadmadi B, Adriani M. Ekstrak Kelopak Rosella Merah (Hibiscus sabdariffa Linn.) Mampu Memperbaiki Histopatologi Hepar Tikus Wistar yang Diberi Paparan Asap Rokok. J Kesehat Andalas. 2018;6(3):696.
5) Pratiwi SR, Lorensia A, Suryadinata RV. Asupan Vitamin C dan E Dengan SQ-FFQ terhadap Fungsi Paru Perokok dan Non-Perokok. Media Kesehat Masy Indones. 2018;14(2):101.
6) Fitria F, Triandhini RIN. R, Mangimbulude JC, Karwur FF. Merokok dan Oksidasi DNA. Sains Med J Kedokt dan Kesehat. 2013;5(2):113.
7) Hall JE. Guyton and hall textbook of medical physiology. 13th ed. London, England: W B Saunders; 2015.
8) Vinay Kumar, Abul K. Abbas JCA. Robbins Basic Pathology. 10th ed. Philadelphia, PA: Elsevier - Health Sciences Division; 2017.
9) Sari GL. Pengaruh Pemberian Jus Buah Naga terhadap Kadar Hormon Testosteron Serum, Jumlah dan Morfologi Spermatozoa Rattus Norvegicus Strain Wistar Albino yang Terpapar Asap Rokok [Internet]. Universitas Andalas; 2019. Available from: http://scholar.unand.ac.id/id/eprint/49791
10) Husen IR, Sastramihardja HS. pada Tikus Model Hepatitis The Hepatoprotective Effect of Rosella ( Hibiscus sabdariffa L .) on Hepatitis Model Rats. Mkb. 2009;44(2):83–9.
11) Clifford T, Howatson G, West DJ, Stevenson EJ. The potential benefits of red beetroot supplementation in health and disease. Nutrients. 2015;7(4):2801–22.
12) Rebecca OPS, Boyce AN, Chandran S. Pigment identification and antioxidant properties of red dragon fruit (Hylocereus polyrhizus). African J Biotechnol. 2010;9(10):1450–4.
13) Nurliyana R, Syed Zahir I, Mustapha Suleiman K, Aisyah MR, Kamarul Rahim K. Antioxidant study of pulps and peels of dragon fruits: A comparative study. Int Food Res J. 2010;17(2):367–75.
14) Bayu Surya Putra IGG, Simamora D. Potensi Jus Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Perbaikan Jaringan Organ Otak Tikus (Rattus Norvegicus) Diabetes. J Ilm Kedokt Wijaya Kusuma. 2019;8(2):84–95.
15) Tirtosastro S, Murdiyati DAS, Penelitian B, Tembakau T, Serat D, Raya J, et al. Kandungan Kimia Tembakau dan Rokok. 2010;2:33–43.
16) Santosa. Kebijakan Pemerintah Daerah tentang Kawasan tanpa Rokok dalam Peningkatan Kesehatan Masyarakat. Huk dan Din Masy. 2013;10(2):177–87.
17) Kusuma DA, Yuwono SS, Siti D, Wulan N, Jurusan A, Pertanian TH, et al. Studi Kadar Nikotin dan Tar Sembilan Merk Rokok Kretek Filter yang Beredar di Wilayah Kabupaten Nganjuk. JTeknologi Pertan. 2017;5(3):151–5.
18) Laurencia E, Tjandra O. Identifikasi Senyawa Kimia Ekstrak Metanol Buah Naga Merah (Hylocereus polyrhiz) Dengan Kromatografi Gas. Tarumanagara Med J. 2018;1(1):67–73.
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